PPARD

Across TCGA patient cohorts, PPARD mutation is significantly associated with the RNA expression of many other genes, with 2,937 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPARD-associated genes across cancer lineages are RN7SL134P, CCL4, and MIR107. Each is linked with PPARD in more than 2 cancer types. Because this analysis shows association rather than direction, both PPARD-to-partner and partner-to-PPARD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by PPARD-low versus PPARD-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPARD→partner) and Y-score (partner→PPARD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL134P →	+0.143	+3.926	.002	.005	3	3
UCEC	CCL4 →	+0.808	+1.947	.001	.003	3	2
CESC	MIR107 →	+0.111	+4.030	.004	.008	3	2
CESC	EIF4A1P13 →	+0.191	+3.520	.001	<.001	3	2
UCEC	LSM10 →	+0.452	+4.010	<.001	<.001	3	2
UCEC	TMEM222 →	+0.341	+3.743	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,937 associations by consensus.

RN7SL134P by PPARD expression — BLCA

Explore this box plot interactively →