PPARD

Across TCGA pan-cancer cohorts, PPARD RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PPARD’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPARD RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PPARD is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where PPARD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPARD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.328	<.001	11	view →
KIRC	Female	All	+0.972	<.001	11	view →
COAD	Female	II,III,IV	−0.927	<.001	10	view →
LIHC	Female	II,III,IV	+1.334	<.001	9	view →
BRCA	All	IV	+0.609	.003	8	view →
THCA	Male	III,IV	−0.551	.002	7	view →
LUAD	All	II,III,IV	+0.665	<.001	6	view →
UCEC	All	All	+0.503	.004	6	view →
KICH	All	All	−0.472	<.001	5	view →
LUSC	Male	All	+0.459	<.001	5	view →
CHOL	Male	All	+2.421	<.001	4	view →
READ	All	All	−0.786	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PPARD–HNSC

Open the HNSC breakdown →