PPARD

Across TCGA patient cohorts, PPARD mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPARD-associated genes across cancer lineages are Notch1, PDCD4, and Caspase-7-cleavedD198. Each is linked with PPARD in more than 3 cancer types. Because this analysis shows association rather than direction, both PPARD-to-partner and partner-to-PPARD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PPARD-low versus PPARD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPARD→partner) and Y-score (partner→PPARD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.204	+2.009	<.001	.017	3	2
UCEC	PDCD4 →	-0.601	-3.169	.001	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.821	+2.321	<.001	.006	1	4
UCEC	EGFR_pY1068 →	-0.282	-3.169	.006	.018	3	1
UCEC	MAPK_pT202_Y204 →	-0.438	-2.321	.023	.034	3	1
UCEC	MEK1 →	+0.440	+3.584	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Notch1 by PPARD expression — UCEC

Explore this box plot interactively →