PPARD

Across TCGA cell cohorts, PPARD RNA expression is significantly associated with the go_rna of many other GO terms, with 4,815 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PPARD-associated GO terms across cancer lineages are Positive regulation of skeletal muscle tissue regeneration, Regulation of skeletal muscle tissue regeneration, and Actin filament organization. Each is linked with PPARD in more than 14 cancer types. Because this analysis shows association rather than direction, both PPARD-to-partner and partner-to-PPARD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of skeletal muscle tissue regeneration grouped by PPARD-low versus PPARD-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPARD→partner) and Y-score (partner→PPARD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of skeletal muscle tissue regeneration →	+0.206	+1.277	<.001	<.001	3	15
BREAST	Regulation of skeletal muscle tissue regeneration →	+0.243	+0.966	<.001	<.001	3	15
BONE	Actin filament organization →	+0.118	+1.095	<.001	<.001	3	13
LUNG_SCLC	Regulation of fibroblast proliferation →	+0.126	+1.663	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Nuclear receptor-mediated signaling pathway →	+0.100	+0.878	<.001	<.001	3	12
BONE	Cytosolic transport →	+0.073	+0.862	<.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,815 associations by consensus.

Positive regulation of skeletal muscle tissue regeneration by PPARD expression — BONE

Explore this box plot interactively →