PPARD

Across TCGA cell cohorts, PPARD mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPARD-associated genes across cancer lineages are SGIP1, SEMG2, and TBC1D21. Each is linked with PPARD in more than 1 cancer types. Because this analysis shows association rather than direction, both PPARD-to-partner and partner-to-PPARD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SGIP1 grouped by PPARD-low versus PPARD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPARD→partner) and Y-score (partner→PPARD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SGIP1 →	+0.549	+3.626	.004	.003	3	1
LARGE_INTESTINE	SEMG2 →	+0.420	+2.878	.003	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	BPY2 →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	BPY2B →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	BPY2C →	+0.012	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

SGIP1 by PPARD expression — LARGE_INTESTINE

Explore this box plot interactively →