PPAN

Across TCGA pan-cancer cohorts, PPAN mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPAN data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPAN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPAN expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where PPAN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	1.000	0.335	.036	8	view →
UCEC	DFS	Median	III,IV	0.484	1.000	.049	8	view →
PDAC	DFS	Quartile	III,IV	0.200	0.968	.017	3	view →
CCRCC	DFS	Median	III,IV	0.428	0.707	.025	3	view →
LSCC	OS	Median	II,III,IV	0.910	1.000	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPAN–HNSC (DFS)

Open the HNSC breakdown →