POU5F2

Across TCGA patient cohorts, POU5F2 mutation is significantly associated with the RNA expression of many other genes, with 747 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU5F2-associated genes across cancer lineages are SRSF6P1, GRAMD4P6, and RNU6-205P. Each is linked with POU5F2 in more than 2 cancer types. Because this analysis shows association rather than direction, both POU5F2-to-partner and partner-to-POU5F2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRSF6P1 grouped by POU5F2-low versus POU5F2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU5F2→partner) and Y-score (partner→POU5F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SRSF6P1 →	+0.086	+5.969	<.001	.002	3	3
SKCM	GRAMD4P6 →	+0.041	+3.900	<.001	.008	3	3
BRCA	RNU6-205P →	+0.252	+8.055	<.001	.007	3	2
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
KIRP	RN7SL188P →	+0.198	+5.928	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 747 associations by consensus.

SRSF6P1 by POU5F2 expression — CESC

Explore this box plot interactively →