POU5F1P5

Across TCGA pan-cancer cohorts, POU5F1P5 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of POU5F1P5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where POU5F1P5 RNA is repressed in tumor relative to normal tissue. In most cancer types POU5F1P5 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and KIRC are the cancer types where POU5F1P5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POU5F1P5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.045	.010	2	view →
COAD	Female	II,III,IV	−0.040	.040	1	view →
KIRC	All	IV	−0.035	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

POU5F1P5–THCA

Open the THCA breakdown →