POU5F1P3

Across TCGA pan-cancer cohorts, POU5F1P3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated POU5F1P3 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POU5F1P3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated POU5F1P3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

HNSC, PAAD, and KIRC are the cancer types where POU5F1P3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.508	0.239	.002	46	view →
PAAD	DFS	Tertile	II,III,IV	0.585	0.325	.005	35	view →
KIRC	DFS	Tertile	All	0.556	0.735	.001	32	view →
UCS	DFS	Tertile	IV	0.956	0.250	.024	24	view →
THCA	OS	Quartile	III,IV	0.753	1.000	.013	24	view →
COAD	DFS	Median	II,III,IV	0.549	0.731	.002	23	view →
PRAD	DFS	Median	All	0.710	0.829	<.001	22	view →
READ	DFS	Tertile	IV	0.465	0.802	.018	19	view →
UVM	DFS	Median	III,IV	0.293	0.745	.016	15	view →
SKCM	OS	Quartile	II,III,IV	0.489	0.213	.004	14	view →
KIRP	DFS	Quartile	IV	0.055	1.000	.024	12	view →
MESO	OS	Median	All	0.630	0.456	.030	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

POU5F1P3–HNSC (DFS)

Open the HNSC breakdown →