POU class 5 homeobox 1 pseudogene 3Genealiases: OTF3L · POU5F1L · POU5FLC12
Q-omics provides the consensus-scored POU5F1P3 profile across patient tissues and cancer cell-line models. POU5F1P3 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, POU5F1P3 is differentially expressed in 8, with the highest sampling consensus in KIRC. Additionally, POU5F1P3 RNA expression shows 18,403 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight HNSC, KIRC, and THYM as cancer lineages where POU5F1P3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for POU5F1P3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes POU5F1P3 survival associations across molecular data types. POU5F1P3 RNA expression shows survival associations in the most cancer types (26). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible POU5F1P3 RNA expression–survival associations across cancer types. High POU5F1P3 expression shows unfavorable associations in KIRC, THCA and COAD, but favorable associations in HNSC, PAAD and UCS. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .002). Together, the overview and detailed table identify HNSC as the clearest survival context for POU5F1P3 RNA expression.
This table summarizes POU5F1P3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for POU5F1P3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. POU5F1P3 shows lower tumor expression in BRCA and UCEC and higher tumor expression in KIRC, HNSC, COAD and CHOL. The KIRC box plot shows higher POU5F1P3 RNA expression in tumor versus normal tissue (log2 FC = +0.358, t-test p < 0.001).
This table shows molecular features associated with POU5F1P3 in patient tissues and cancer cell lines. In patient samples, POU5F1P3 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, POU5F1P3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD.
