Across TCGA patient cohorts, POU5F1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,560 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible POU5F1-associated proteins across cancer lineages are USP39, TOP2A_S1247, and TOP2A_T1470. Each is linked with POU5F1 in more than 2 cancer types. Because this analysis shows association rather than direction, both POU5F1-to-partner and partner-to-POU5F1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POU5F1→partner) and Y-score (partner→POU5F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	USP39 →	+0.211	+0.747	.006	.006	3	3
BRCA	TOP2A_S1247 →	+0.728	+0.795	<.001	<.001	3	3
HNSC	TOP2A_T1470 →	+0.866	+0.831	<.001	<.001	3	3
BRCA	TPX2 →	+0.715	+0.836	<.001	<.001	3	3
HNSC	TRRAP →	+0.164	+0.525	<.001	<.001	3	3
BRCA	PNO1 →	+0.256	+0.536	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,560 associations by consensus.

Exploration

POU5F1 survival (RNA) · tumor vs normal (RNA) · all POU5F1 data types