Across TCGA patient cohorts, POU5F1 mutation is significantly associated with the RNA expression of many other genes, with 917 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU5F1-associated genes across cancer lineages are RNU4-21P, RNA5SP323, and NAMPTP2. Each is linked with POU5F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU5F1-to-partner and partner-to-POU5F1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU5F1→partner) and Y-score (partner→POU5F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-21P →	+0.654	+3.000	.005	.001	3	2
UCEC	RNA5SP323 →	+0.509	+2.164	.002	.002	3	2
UCEC	NAMPTP2 →	+0.029	+2.912	.005	.009	3	2
SKCM	RNU6-142P →	+0.237	+3.508	<.001	.006	3	2
UCEC	RPS28P1 →	+0.126	+2.912	<.001	.009	3	1
UCEC	CYP4F36P →	+0.252	+2.368	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 917 associations by consensus.

Exploration

POU5F1 survival (RNA) · tumor vs normal (RNA) · all POU5F1 data types