POU4F2

Across TCGA patient cohorts, POU4F2 mutation is significantly associated with the RNA expression of many other genes, with 2,649 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU4F2-associated genes across cancer lineages are RN7SKP86, LSM10, and CIB1. Each is linked with POU4F2 in more than 2 cancer types. Because this analysis shows association rather than direction, both POU4F2-to-partner and partner-to-POU4F2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP86 grouped by POU4F2-low versus POU4F2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU4F2→partner) and Y-score (partner→POU4F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SKP86 →	+0.140	+3.507	<.001	.005	3	3
SKCM	LSM10 →	+0.549	+3.182	<.001	.009	3	3
UCEC	CIB1 →	+0.341	+3.818	.006	<.001	3	3
UCEC	TLR5 →	-0.493	-1.927	<.001	.001	3	3
UCEC	CCDC134 →	+0.379	+1.436	.001	.001	3	3
UCEC	TXN2 →	+0.215	+1.511	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,649 associations by consensus.

RN7SKP86 by POU4F2 expression — CESC

Explore this box plot interactively →