POU4F2

Across TCGA patient cohorts, POU4F2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU4F2-associated genes across cancer lineages are INPP4B, YAP_pS127, and EGFR_pY1068. Each is linked with POU4F2 in more than 2 cancer types. Because this analysis shows association rather than direction, both POU4F2-to-partner and partner-to-POU4F2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by POU4F2-low versus POU4F2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU4F2→partner) and Y-score (partner→POU4F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.192	-1.584	.039	.032	3	3
COAD	YAP_pS127 →	-0.229	-2.313	.032	.006	3	3
COAD	EGFR_pY1068 →	-0.266	-1.861	.029	.049	3	2
UCEC	A-Raf_pS299 →	-0.081	-1.222	.018	.032	3	2
UCEC	JNK_pT183_Y185 →	-0.138	-1.334	.004	.006	3	2
UCEC	PCNA →	+0.146	+1.169	.018	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

INPP4B by POU4F2 expression — UCEC

Explore this box plot interactively →