POU4F2

Across TCGA cell cohorts, POU4F2 mutation is significantly associated with the RNA expression of many other genes, with 159 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POU4F2-associated genes across cancer lineages are KRTAP10-1, SCGB1C1, and HIGD1C. Each is linked with POU4F2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU4F2-to-partner and partner-to-POU4F2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-1 grouped by POU4F2-low versus POU4F2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU4F2→partner) and Y-score (partner→POU4F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KRTAP10-1 →	+0.019	+5.169	<.001	.005	3	1
CNS	SCGB1C1 →	+0.242	+4.981	<.001	.008	3	1
LUNG_NSCLC_LUAD	HIGD1C →	+0.052	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	GAGE12H →	+1.476	+4.481	<.001	.001	3	1
LARGE_INTESTINE	GCAT →	+1.374	+3.364	<.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.645	+3.451	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

KRTAP10-1 by POU4F2 expression — BREAST

Explore this box plot interactively →