POU2F2

Across TCGA cell cohorts, POU2F2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POU2F2-associated genes across cancer lineages are OR3A1, FTMT, and SIX3. Each is linked with POU2F2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU2F2-to-partner and partner-to-POU2F2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR3A1 grouped by POU2F2-low versus POU2F2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU2F2→partner) and Y-score (partner→POU2F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR3A1 →	+0.093	+5.285	<.001	.003	3	1
STOMACH	FTMT →	+0.066	+5.285	<.001	.003	3	1
LARGE_INTESTINE	SIX3 →	+0.577	+3.374	.001	.005	3	1
LARGE_INTESTINE	CENPVL3 →	+0.132	+2.657	.003	.007	3	1
BLOOD_Lymphoma	HTR3D →	+0.015	+5.247	<.001	.001	3	1
CNS	FGF3 →	+0.043	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR3A1 by POU2F2 expression — STOMACH

Explore this box plot interactively →