POU2F1

Across TCGA pan-cancer cohorts, POU2F1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated POU2F1 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher POU2F1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated POU2F1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where POU2F1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.897	0.667	.008	30	view →
PDAC	DFS	Tertile	All	0.642	0.831	.008	11	view →
HNSC	DFS	Tertile	II,III,IV	0.683	0.824	.027	7	view →
LSCC	DFS	Median	II,III,IV	0.451	0.877	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

POU2F1–CCRCC (OS)

Open the CCRCC breakdown →