POU2F1

Across TCGA patient cohorts, POU2F1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU2F1-associated genes across cancer lineages are A-Raf_pS299, C-Raf, and Cyclin-B1. Each is linked with POU2F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU2F1-to-partner and partner-to-POU2F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by POU2F1-low versus POU2F1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU2F1→partner) and Y-score (partner→POU2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.167	-3.321	<.001	<.001	3	2
UCEC	C-Raf →	+0.170	+2.115	.001	.017	3	2
UCEC	Cyclin-B1 →	+0.612	+1.700	.003	.042	3	2
UCEC	ERK2 →	+0.187	+2.584	.009	.010	3	1
UCEC	Lck →	+0.200	+2.584	.007	.010	3	1
UCEC	MSH6 →	-0.313	-1.990	.011	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

A-Raf_pS299 by POU2F1 expression — UCEC

Explore this box plot interactively →