POU2F1

Across TCGA cell cohorts, POU2F1 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POU2F1-associated genes across cancer lineages are MRGPRG, SPINK9, and TEX50. Each is linked with POU2F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU2F1-to-partner and partner-to-POU2F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRG grouped by POU2F1-low versus POU2F1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU2F1→partner) and Y-score (partner→POU2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MRGPRG →	+0.029	+4.544	<.001	.003	3	2
LARGE_INTESTINE	SPINK9 →	+0.230	+2.793	<.001	.002	3	2
KIDNEY	TEX50 →	+0.026	+5.000	<.001	.005	3	1
BREAST	SLC17A2 →	+0.010	+4.781	<.001	.003	3	1
LARGE_INTESTINE	MCAT →	+0.800	+3.082	<.001	.007	3	1
LARGE_INTESTINE	SH3GL2 →	+1.511	+3.667	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

MRGPRG by POU2F1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →