POU1F1

Across TCGA patient cohorts, POU1F1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,929 significant associations in total. STAD shows the largest number of these associations.

The most reproducible POU1F1-associated GO terms across cancer lineages are Protein localization to vacuole, Establishment of protein localization to vacuole, and Endosome organization. Each is linked with POU1F1 in more than 15 cancer types. Because this analysis shows association rather than direction, both POU1F1-to-partner and partner-to-POU1F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to vacuole grouped by POU1F1-low versus POU1F1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POU1F1→partner) and Y-score (partner→POU1F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Protein localization to vacuole →	+0.056	+0.087	<.001	<.001	3	16
STAD	Establishment of protein localization to vacuole →	+0.056	+0.086	<.001	<.001	3	16
STAD	Endosome organization →	+0.055	+0.085	<.001	<.001	3	16
STAD	Protein localization to endoplasmic reticulum →	+0.062	+0.084	<.001	<.001	3	15
STAD	Protein quality control for misfolded or incompletely synthesized proteins →	+0.047	+0.086	<.001	<.001	3	15
ESCA	Membrane lipid metabolic process →	+0.053	+0.128	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,929 associations by consensus.

Protein localization to vacuole by POU1F1 expression — STAD

Explore this box plot interactively →