POU1F1

Across TCGA patient cohorts, POU1F1 mutation is significantly associated with the RNA expression of many other genes, with 2,458 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU1F1-associated genes across cancer lineages are EIF1, TOLLIP, and DDX24. Each is linked with POU1F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU1F1-to-partner and partner-to-POU1F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF1 grouped by POU1F1-low versus POU1F1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU1F1→partner) and Y-score (partner→POU1F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF1 →	+0.341	+3.540	.005	.002	3	2
UCEC	TOLLIP →	+0.469	+3.108	<.001	<.001	3	2
UCEC	DDX24 →	+0.424	+3.353	.002	.005	3	2
SKCM	CTSLP1 →	+0.081	+2.964	<.001	.001	3	2
BRCA	TSPY18P →	+0.144	+9.057	<.001	.003	3	2
READ	BPNT2P →	+0.148	+6.681	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,458 associations by consensus.

EIF1 by POU1F1 expression — UCEC

Explore this box plot interactively →