POU1F1

Across TCGA patient cohorts, POU1F1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POU1F1-associated genes across cancer lineages are MEK1, ASNS, and Fibronectin. Each is linked with POU1F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POU1F1-to-partner and partner-to-POU1F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by POU1F1-low versus POU1F1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POU1F1→partner) and Y-score (partner→POU1F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.477	+3.169	.009	.019	3	2
UCEC	ASNS →	+0.577	+3.169	.001	.019	3	2
UCEC	Fibronectin →	-0.334	-2.312	.043	.034	3	1
UCEC	INPP4B →	-0.339	-2.999	.036	.035	3	1
UCEC	CD49b →	-0.397	-3.446	.005	.005	3	1
UCEC	C-Raf →	+0.172	+2.321	.016	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MEK1 by POU1F1 expression — UCEC

Explore this box plot interactively →