POU1F1

Across TCGA cell cohorts, POU1F1 RNA expression is significantly associated with the go_rna of many other GO terms, with 728 significant associations in total. BONE shows the largest number of these associations.

The most reproducible POU1F1-associated GO terms across cancer lineages are Intracellular pH reduction, Regulation of mRNA splicing, via spliceosome, and RNA catabolic process. Each is linked with POU1F1 in more than 3 cancer types. Because this analysis shows association rather than direction, both POU1F1-to-partner and partner-to-POU1F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular pH reduction grouped by POU1F1-low versus POU1F1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POU1F1→partner) and Y-score (partner→POU1F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Intracellular pH reduction →	+0.055	+0.051	.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA splicing, via spliceosome →	+0.097	+0.021	<.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	RNA catabolic process →	+0.061	+0.016	.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	Nucleic acid catabolic process →	+0.056	+0.015	<.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	Spliceosomal complex assembly →	+0.098	+0.027	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	Regulation of RNA splicing →	+0.100	+0.026	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 728 associations by consensus.

Intracellular pH reduction by POU1F1 expression — PANCREAS

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