Across TCGA patient cohorts, POTEH mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POTEH-associated genes across cancer lineages are Cyclin-B1, C-Raf, and Notch1. Each is linked with POTEH in more than 3 cancer types. Because this analysis shows association rather than direction, both POTEH-to-partner and partner-to-POTEH results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEH→partner) and Y-score (partner→POTEH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-B1 →	+1.256	+3.000	<.001	.036	2	4
UCEC	C-Raf →	+0.231	+3.169	<.001	.019	3	2
UCEC	Notch1 →	+0.204	+3.700	.001	.001	3	2
UCEC	Annexin-1 →	+0.686	+3.019	.005	.019	3	2
UCEC	VEGFR2 →	+0.404	+2.999	.003	.035	3	2
UCEC	Dvl3 →	+0.265	+2.584	.001	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Exploration

POTEH survival (RNA) · tumor vs normal (RNA) · all POTEH data types