Across TCGA pan-cancer cohorts, POTEH RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated POTEH data layer compared with 10 for mutation status.
The strongest signal is observed in kidney chromophobe (KICH), where higher POTEH RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated POTEH expression acts as an unfavorable survival marker, although some lineages such as BRCA and SCLC show a favorable association.
KICH, BRCA, and LUAD are the cancer types where POTEH RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.