Across TCGA cell cohorts, POTEH mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible POTEH-associated genes across cancer lineages are NPHS2, MSGN1, and LMNTD1. Each is linked with POTEH in more than 1 cancer types. Because this analysis shows association rather than direction, both POTEH-to-partner and partner-to-POTEH results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEH→partner) and Y-score (partner→POTEH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NPHS2 →	+0.038	+3.215	<.001	.007	3	2
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	LMNTD1 →	+0.116	+3.554	.006	.007	3	1
LUNG_NSCLC_LUAD	AGXT2 →	+0.012	+3.786	<.001	.001	3	1
LUNG_NSCLC_LUAD	CSN1S1 →	+0.027	+3.887	<.001	.002	3	1
LUNG_NSCLC_LUAD	PPP1R3A →	+0.019	+4.228	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

POTEH survival (RNA) · tumor vs normal (RNA) · all POTEH data types