Across TCGA pan-cancer cohorts, POTEF-AS1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of POTEF-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POTEF-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POTEF-AS1 is over-expressed in tumor.

HNSC, BRCA, and LUSC are the cancer types where POTEF-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POTEF-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.050	.026	8	view →
BRCA	All	All	+0.273	<.001	4	view →
LUSC	All	All	+0.025	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: POTEF-AS1 RNA expression & survival · all POTEF-AS1 data types