Across TCGA patient cohorts, POTEE mutation is significantly associated with the RNA expression of many other genes, with 3,763 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POTEE-associated genes across cancer lineages are SSRP1, NCAPH2, and TRMU. Each is linked with POTEE in more than 3 cancer types. Because this analysis shows association rather than direction, both POTEE-to-partner and partner-to-POTEE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEE→partner) and Y-score (partner→POTEE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SSRP1 →	+0.428	+2.078	.001	<.001	3	4
UCEC	NCAPH2 →	+0.632	+2.584	<.001	<.001	3	4
UCEC	TRMU →	+0.553	+2.694	<.001	<.001	3	4
UCEC	PIMREG →	+0.787	+2.202	<.001	.001	3	4
UCEC	TRAIP →	+0.538	+3.700	<.001	.001	3	4
UCEC	KIFC1 →	+0.638	+1.874	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,763 associations by consensus.

Exploration

POTEE survival (RNA) · tumor vs normal (RNA) · all POTEE data types