POTEB3

Across TCGA patient cohorts, POTEB3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POTEB3-associated genes across cancer lineages are FoxM1, p70-S6K, and PREX1. Each is linked with POTEB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POTEB3-to-partner and partner-to-POTEB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by POTEB3-low versus POTEB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEB3→partner) and Y-score (partner→POTEB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.313	+3.000	.036	.037	3	1
UCEC	p70-S6K →	+0.270	+3.026	.015	.019	1	1
UCEC	PREX1 →	+0.346	+3.000	.029	.037	1	1
UCEC	STAT3_pY705 →	-0.424	-3.000	.005	.037	1	1
UCEC	STAT5a →	+0.566	+3.000	.014	.037	1	1
UCEC	Cyclin-B1 →	+0.792	+3.000	.014	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FoxM1 by POTEB3 expression — UCEC

Explore this box plot interactively →