POTEB3

Across TCGA pan-cancer cohorts, POTEB3 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated POTEB3 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher POTEB3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated POTEB3 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

KICH, PAAD, and LIHC are the cancer types where POTEB3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.568	0.921	<.001	90	view →
PAAD	DFS	Tertile	All	0.077	0.486	<.001	90	view →
LIHC	OS	Tertile	All	0.346	0.788	<.001	90	view →
READ	OS	Tertile	II,III,IV	0.056	0.934	<.001	72	view →
STAD	DFS	Tertile	All	0.378	0.741	<.001	72	view →
LUSC	OS	Tertile	II,III,IV	0.189	0.636	<.001	69	view →
MESO	DFS	Tertile	III,IV	0.088	0.421	<.001	63	view →
KIRC	OS	Tertile	All	0.672	0.810	.013	57	view →
COAD	OS	Tertile	All	0.163	0.870	<.001	54	view →
UCS	OS	Tertile	All	0.269	0.693	.020	36	view →
KIRP	DFS	Tertile	All	0.620	0.861	.006	21	view →
THYM	DFS	Tertile	All	0.108	0.826	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

POTEB3–KICH (DFS)

Open the KICH breakdown →