POTEB3

Across TCGA cell cohorts, POTEB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 235 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POTEB3-associated GO terms across cancer lineages are Regulation of peptide secretion, Cardiac muscle cell membrane repolarization, and Regulation of peptide hormone secretion. Each is linked with POTEB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POTEB3-to-partner and partner-to-POTEB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of peptide secretion grouped by POTEB3-low versus POTEB3-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEB3→partner) and Y-score (partner→POTEB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of peptide secretion →	-0.042	-0.028	<.001	.008	3	2
BLOOD_Leukemia	Cardiac muscle cell membrane repolarization →	+0.146	+0.011	<.001	.007	3	2
CNS	Regulation of peptide hormone secretion →	-0.039	-0.029	.001	.006	3	2
BLOOD_Leukemia	Intracellular magnesium ion homeostasis →	+0.107	+0.011	<.001	.003	3	2
BLOOD_Leukemia	Myotube differentiation involved in skeletal muscle regeneration →	+0.202	+0.015	<.001	.006	3	2
BLOOD_Leukemia	Eosinophil mediated immunity →	+0.146	+0.015	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 235 associations by consensus.

Regulation of peptide secretion by POTEB3 expression — CNS

Explore this box plot interactively →