Across TCGA patient cohorts, POTEA mutation is significantly associated with the RNA expression of many other genes, with 2,387 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POTEA-associated genes across cancer lineages are RPS15AP32, TIMM44, and SDHB. Each is linked with POTEA in more than 2 cancer types. Because this analysis shows association rather than direction, both POTEA-to-partner and partner-to-POTEA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEA→partner) and Y-score (partner→POTEA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPS15AP32 →	+0.020	+3.903	<.001	.007	3	3
UCEC	TIMM44 →	+0.425	+2.447	.001	.001	3	3
UCEC	SDHB →	+0.474	+3.625	.001	.001	3	3
UCEC	C4orf46 →	+0.675	+2.708	<.001	.003	3	3
BRCA	LINC02219 →	+0.077	+2.875	.003	.007	3	2
COAD	RNU5E-8P →	+0.250	+3.973	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,387 associations by consensus.

Exploration

POTEA survival (RNA) · tumor vs normal (RNA) · all POTEA data types