Across TCGA patient cohorts, POTEA mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POTEA-associated genes across cancer lineages are PCNA, PEA-15_pS116, and STAT3_pY705. Each is linked with POTEA in more than 1 cancer types. Because this analysis shows association rather than direction, both POTEA-to-partner and partner-to-POTEA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEA→partner) and Y-score (partner→POTEA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.205	+2.807	.030	.003	3	2
UCEC	PEA-15_pS116 →	+0.547	+2.584	<.001	.010	3	2
UCEC	STAT3_pY705 →	-0.351	-1.874	.002	.049	3	2
UCEC	Bax →	+0.258	+2.321	.013	.033	3	2
SKCM	Caveolin-1 →	-0.767	-3.169	.009	.018	3	2
BRCA	p70-S6K →	+0.547	+2.820	.007	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Exploration

POTEA survival (RNA) · tumor vs normal (RNA) · all POTEA data types