POT1

Across TCGA pan-cancer cohorts, POT1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated POT1 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher POT1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated POT1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

UCEC, GBM, and LUAD are the cancer types where POT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.556	1.000	.028	16	view →
GBM	OS	Tertile	All	0.625	0.293	.010	6	view →
LUAD	DFS	Median	II,III,IV	0.754	0.329	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

POT1–UCEC (OS)

Open the UCEC breakdown →