POT1

Across TCGA patient cohorts, POT1 mutation is significantly associated with the RNA expression of many other genes, with 2,576 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POT1-associated genes across cancer lineages are RPL32P14, S100A11P7, and RNA5SP405. Each is linked with POT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both POT1-to-partner and partner-to-POT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL32P14 grouped by POT1-low versus POT1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POT1→partner) and Y-score (partner→POT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL32P14 →	+0.066	+5.225	<.001	.001	3	3
STAD	S100A11P7 →	+0.696	+4.090	<.001	.004	3	3
UCEC	RNA5SP405 →	+0.201	+2.724	<.001	.002	3	3
CESC	CDRT15P7 →	+0.058	+4.669	<.001	.007	3	2
CESC	MIR8053 →	+0.361	+5.342	<.001	.002	3	2
HNSC	RN7SKP121 →	+0.159	+5.468	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,576 associations by consensus.

RPL32P14 by POT1 expression — SKCM

Explore this box plot interactively →