POT1

Across TCGA patient cohorts, POT1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POT1-associated genes across cancer lineages are MEK1, Notch1, and Annexin-1. Each is linked with POT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POT1-to-partner and partner-to-POT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by POT1-low versus POT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POT1→partner) and Y-score (partner→POT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.364	+2.415	.004	.003	3	2
UCEC	Notch1 →	+0.121	+1.598	.013	.040	3	2
UCEC	Annexin-1 →	+0.610	+1.926	<.001	.008	3	2
UCEC	ATM →	-0.483	-2.321	.002	.005	3	2
UCEC	EGFR_pY1068 →	-0.214	-2.087	.014	.005	3	1
UCEC	EGFR →	-0.143	-1.440	.009	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MEK1 by POT1 expression — UCEC

Explore this box plot interactively →