POT1

Across TCGA cell cohorts, POT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,058 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POT1-associated GO terms across cancer lineages are Regulation of telomeric D-loop disassembly, Telomere maintenance via telomerase, and Positive regulation of isotype switching to IgG isotypes. Each is linked with POT1 in more than 18 cancer types. Because this analysis shows association rather than direction, both POT1-to-partner and partner-to-POT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomeric D-loop disassembly grouped by POT1-low versus POT1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POT1→partner) and Y-score (partner→POT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of telomeric D-loop disassembly →	+0.116	+1.043	<.001	<.001	3	19
OVARY	Telomere maintenance via telomerase →	+0.112	+0.893	<.001	<.001	3	15
BONE	Positive regulation of isotype switching to IgG isotypes →	+0.136	+0.803	<.001	<.001	3	14
LARGE_INTESTINE	DNA biosynthetic process →	+0.073	+0.597	<.001	.001	3	13
LUNG_SCLC	Centrosome cycle →	+0.087	+0.876	<.001	<.001	3	12
BREAST	Telomere assembly →	+0.128	+0.725	.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,058 associations by consensus.

Regulation of telomeric D-loop disassembly by POT1 expression — OESOPHAGUS

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