POSTN

Across TCGA pan-cancer cohorts, POSTN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POSTN data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher POSTN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POSTN expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

COAD, LUAD, and CCRCC are the cancer types where POSTN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.885	1.000	.019	36	view →
LUAD	OS	Median	III,IV	0.663	1.000	.007	20	view →
CCRCC	OS	Median	II,III,IV	0.846	0.635	.020	8	view →
LSCC	DFS	Quartile	All	0.317	0.911	.006	5	view →
PDAC	OS	Tertile	III,IV	0.460	1.000	.049	1	view →
HNSC	OS	Median	IV	0.643	0.829	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POSTN–COAD (DFS)

Open the COAD breakdown →