POSTN

Across TCGA patient cohorts, POSTN mutation is significantly associated with the RNA expression of many other genes, with 4,726 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POSTN-associated genes across cancer lineages are ACYP1, PLD4, and SLC26A6. Each is linked with POSTN in more than 3 cancer types. Because this analysis shows association rather than direction, both POSTN-to-partner and partner-to-POSTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACYP1 grouped by POSTN-low versus POSTN-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POSTN→partner) and Y-score (partner→POSTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ACYP1 →	+0.583	+3.203	.001	.008	3	4
STAD	PLD4 →	-0.756	-3.321	.005	.009	3	4
LUAD	SLC26A6 →	+0.655	+3.807	<.001	<.001	3	4
UCEC	BUB3 →	+0.391	+2.323	<.001	<.001	3	4
LUSC	GPIHBP1 →	-0.685	-3.664	.002	.001	3	4
COAD	GFRA1 →	-0.478	-3.269	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,726 associations by consensus.

ACYP1 by POSTN expression — STAD

Explore this box plot interactively →