PORCN

Across TCGA pan-cancer cohorts, PORCN mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PORCN’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where PORCN mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PORCN is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

LSCC, LUAD, and HNSC are the cancer types where PORCN tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PORCN mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.336	<.001	7	view →
LUAD	Female	All	+0.361	.007	3	view →
HNSC	Male	IV	−0.263	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PORCN–LSCC

Open the LSCC breakdown →