PORCN

Across TCGA cell cohorts, PORCN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,508 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PORCN-associated GO terms across cancer lineages are Protein lipidation, Lipoprotein biosynthetic process, and Maintenance of protein location in cell. Each is linked with PORCN in more than 14 cancer types. Because this analysis shows association rather than direction, both PORCN-to-partner and partner-to-PORCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein lipidation grouped by PORCN-low versus PORCN-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PORCN→partner) and Y-score (partner→PORCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Protein lipidation →	+0.191	+2.973	<.001	<.001	3	15
LIVER	Lipoprotein biosynthetic process →	+0.139	+2.460	.001	.001	3	13
LIVER	Maintenance of protein location in cell →	+0.192	+2.452	<.001	<.001	3	12
LIVER	Maintenance of protein location →	+0.197	+2.452	<.001	<.001	3	12
SOFT_TISSUE	Protein secretion →	+0.088	+1.362	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of hemostasis →	+0.250	+1.440	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,508 associations by consensus.

Protein lipidation by PORCN expression — LIVER

Explore this box plot interactively →