PORCN

Across TCGA cell cohorts, PORCN mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible PORCN-associated genes across cancer lineages are OR10W1, PNLIPRP1, and SCGB1D4. Each is linked with PORCN in more than 1 cancer types. Because this analysis shows association rather than direction, both PORCN-to-partner and partner-to-PORCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by PORCN-low versus PORCN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PORCN→partner) and Y-score (partner→PORCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.012	+4.977	.002	.007	3	1
OVARY	PNLIPRP1 →	+0.031	+4.450	<.001	.004	3	1
OVARY	SCGB1D4 →	+0.097	+4.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR10W1 by PORCN expression — LARGE_INTESTINE

Explore this box plot interactively →