POP7

Across TCGA pan-cancer cohorts, POP7 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated POP7 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher POP7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated POP7 expression acts as an unfavorable survival marker.

KIRC, KIRP, and SKCM are the cancer types where POP7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.123	0.805	<.001	42	view →
KIRP	DFS	Median	All	0.519	0.920	.007	12	view →
SKCM	OS	Median	All	0.220	0.787	.001	12	view →
COAD	DFS	Median	All	0.160	0.693	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

POP7–KIRC (OS)

Open the KIRC breakdown →