POP7

Across TCGA pan-cancer cohorts, POP7 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of POP7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POP7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POP7 is over-expressed in tumor.

HNSC, KIRC, and COAD are the cancer types where POP7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POP7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.349	<.001	12	view →
KIRC	All	IV	+0.884	<.001	12	view →
COAD	Female	II,III,IV	+1.256	<.001	11	view →
BLCA	Male	All	+1.048	<.001	11	view →
KIRP	Male	II,III,IV	+0.828	<.001	11	view →
LUAD	Female	III,IV	+1.009	<.001	9	view →
LIHC	Female	II,III,IV	+0.995	<.001	9	view →
STAD	All	II,III,IV	+0.844	<.001	9	view →
LUSC	Female	II,III,IV	+1.358	<.001	8	view →
READ	All	All	+0.815	<.001	7	view →
BRCA	All	III,IV	+0.786	<.001	6	view →
UCEC	All	III,IV	+0.700	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

POP7–HNSC

Open the HNSC breakdown →