POP7

Across TCGA pan-cancer cohorts, POP7 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated POP7 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher POP7 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated POP7 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

PDAC, GBM, and UCEC are the cancer types where POP7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.214	0.476	.014	12	view →
GBM	OS	Quartile	All	0.639	0.911	.006	3	view →
UCEC	DFS	Median	All	0.948	0.865	.042	2	view →
CCRCC	OS	Median	All	0.921	0.787	.045	1	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

POP7–PDAC (OS)

Open the PDAC breakdown →