POP4

Across TCGA pan-cancer cohorts, POP4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POP4 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher POP4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POP4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

CCRCC, LUAD, and UCEC are the cancer types where POP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.667	0.962	<.001	32	view →
LUAD	DFS	Tertile	All	0.451	0.792	.001	27	view →
UCEC	DFS	Median	All	1.000	0.934	.027	6	view →
LSCC	DFS	Tertile	II,III,IV	0.771	0.491	.032	3	view →
PDAC	OS	Quartile	III,IV	0.568	0.986	.030	2	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.898	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POP4–CCRCC (DFS)

Open the CCRCC breakdown →