PON3

Across TCGA cell cohorts, PON3 mutation is significantly associated with the RNA expression of many other genes, with 276 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PON3-associated genes across cancer lineages are SMR3B, DEFB132, and APOL4. Each is linked with PON3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PON3-to-partner and partner-to-PON3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMR3B grouped by PON3-low versus PON3-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PON3→partner) and Y-score (partner→PON3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SMR3B →	+0.795	+5.000	<.001	.006	3	1
LUNG_SCLC	DEFB132 →	+0.012	+5.029	<.001	.006	3	1
LARGE_INTESTINE	APOL4 →	+0.505	+3.369	<.001	.005	3	1
LARGE_INTESTINE	TNRC6B →	+0.941	+3.064	<.001	.009	3	1
LARGE_INTESTINE	FNDC3A →	+0.593	+3.364	.001	.002	3	1
LARGE_INTESTINE	FAH →	-1.030	-3.278	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 276 associations by consensus.

SMR3B by PON3 expression — PANCREAS

Explore this box plot interactively →