PON2

Across TCGA patient cohorts, PON2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,667 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PON2-associated genes across cancer lineages are P2RY8, PON3, and FANCI. Each is linked with PON2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PON2-to-partner and partner-to-PON2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PON2 versus P2RY8 in CCRCC, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PON2→partner) and Y-score (partner→PON2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	P2RY8 →	-0.763	-0.476	<.001	<.001	3	5
LUAD	PON3 →	+1.404	+0.719	<.001	<.001	3	5
OV	FANCI →	-0.736	-0.471	<.001	.001	3	4
HNSC	CLDN12 →	+0.616	+0.550	<.001	<.001	3	4
OV	TOPBP1 →	-0.682	-0.447	<.001	.002	3	4
UCEC	AURKB →	-1.013	-0.562	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,667 associations by consensus.

PON2 vs P2RY8 — CCRCC

Explore this scatter interactively →