PON2

Across TCGA cell cohorts, PON2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PON2-associated genes across cancer lineages are RASGEF1C, ITGAD, and PRAMEF20. Each is linked with PON2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PON2-to-partner and partner-to-PON2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RASGEF1C grouped by PON2-low versus PON2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PON2→partner) and Y-score (partner→PON2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RASGEF1C →	+0.288	+3.404	<.001	.006	3	1
LARGE_INTESTINE	ITGAD →	+0.012	+2.925	<.001	.007	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR2A12 →	+0.026	+3.443	.006	.009	3	1
BLOOD_Leukemia	DMRTC2 →	+0.042	+5.539	<.001	.003	3	1
BLOOD_Leukemia	RNASE11 →	+0.051	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

RASGEF1C by PON2 expression — LARGE_INTESTINE

Explore this box plot interactively →