PON1

Across TCGA pan-cancer cohorts, PON1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PON1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PON1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PON1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where PON1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.929	0.694	.002	48	view →
LUAD	OS	Median	III,IV	0.220	0.618	.008	23	view →
GBM	DFS	Tertile	All	0.578	0.229	.005	13	view →
PDAC	OS	Median	All	0.667	0.972	.001	11	view →
LSCC	DFS	Median	II,III,IV	0.832	1.000	.004	7	view →
OV	DFS	Median	All	1.000	0.607	.004	4	view →
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PON1–CCRCC (DFS)

Open the CCRCC breakdown →